Glyphosate Disorders Soil Enchytraeid Gut Microbiota and Increases Its Antibiotic Resistance Risk
Zhang, Qi Lei, Chaotang Jin, Mingkang Qin, Guoyan Yu, Yitian Qiu, Danyan Wang, Yan Zhang, Ziyao Zhang, Zhenyan Lu, Tao
Zhang, Qi
Lei, Chaotang
Jin, Mingkang
Qin, Guoyan
Yu, Yitian
Qiu, Danyan
Wang, Yan
Zhang, Ziyao
Zhang, Zhenyan
Lu, Tao
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2024-01-18
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Glyphosate Disorders Soil Enchytraeid Gut Microbiota and Increases Its Antibiotic Resistance Risk
Translated Title
Published in
J Agric Food Chem 2024;online ahead of print
Abstract
Pesticides promote the stable development of intensive global agriculture. Nevertheless, their residues in the soil can cause ecological and human health risks. Glyphosate is a popular herbicide and is generally thought to be ecologically safe and nontoxic, but this conclusion has been questioned. Herein, we investigated the interaction among soil fauna (Enchytraeus crypticus) exposed to glyphosate and found that glyphosate induced oxidative stress and detoxification responses in E. crypticus and disturbed their lipid metabolism and digestive systems. We further demonstrated that glyphosate disordered the gut microbiota of E. crypticus and increased the abundance of resistance determinants with significant human health risks. Empirical tests and structural equation models were then used to confirm that glyphosate could cause E. crypticus to generate reactive oxygen species, indirectly interfering with their gut microbiota. Our study provides important implications for deciphering the mechanisms of the ecotoxicity of pesticides under the challenge of worldwide pesticide contamination.