Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis.
Ruesen, Carolien Chaidir, Lidya van Laarhoven, Arjan Dian, Sofiati Ganiem, Ahmad Rizal Nebenzahl-Guimaraes, Hanna Huynen, Martijn A Alisjahbana, Bachti Dutilh, Bas E van Crevel, Reinout
Ruesen, Carolien
Chaidir, Lidya
van Laarhoven, Arjan
Dian, Sofiati
Ganiem, Ahmad Rizal
Nebenzahl-Guimaraes, Hanna
Huynen, Martijn A
Alisjahbana, Bachti
Dutilh, Bas E
van Crevel, Reinout
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis.
Translated Title
Published in
BMC Genomics 2018; 19(1):122
Abstract
Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.