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Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: Role of IgM
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Title
Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: Role of IgM
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Published in
Expl Gerontol 2018; 105:101-8
Abstract
Successful vaccination of elderly persons is often hampered by immunological ageing, leaving part of the elderly population vulnerable for infectious diseases. As an alternative, timely vaccinations might be administered at middle-age, before reaching old age. Studies evaluating the immunological fitness of middle-aged adults are warranted. In this study we compared the immunogenicity of a primary meningococcal vaccination in Dutch middle-aged adults with that in adolescents, in order to gain knowledge on the early signs of immune ageing.