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Updated cost-effectiveness and risk-benefit analysis of two infant rotavirus vaccination strategies in a high-income, low-endemic setting.
Bruijning-Verhagen, P van Dongen, J A P Verberk, J D M Pijnacker, R van Gaalen, R D Klinkenberg, D de Melker, H E Mangen, M-J J
Bruijning-Verhagen, P
van Dongen, J A P
Verberk, J D M
Pijnacker, R
van Gaalen, R D
Klinkenberg, D
de Melker, H E
Mangen, M-J J
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Open Access
Type
Article
Language
en
Date of publication
2018
Year of publication
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s12916-018-1134-3.pdf
Adobe PDF, 1.48 MB
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Title
Updated cost-effectiveness and risk-benefit analysis of two infant rotavirus vaccination strategies in a high-income, low-endemic setting.
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BMC Med 2018; 16(1):168
Abstract
Since 2013, a biennial rotavirus pattern has emerged in the Netherlands with alternating high and low endemic years and a nearly 50% reduction in rotavirus hospitalization rates overall, while infant rotavirus vaccination has remained below 1% throughout. As the rotavirus vaccination cost-effectiveness and risk-benefit ratio in high-income settings is highly influenced by the total rotavirus disease burden, we re-evaluated two infant vaccination strategies, taking into account this recent change in rotavirus epidemiology.