Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers.
Fagotti, Juliane; Targa, Adriano D S; Rodrigues, Lais S; Noseda, Ana Carolina D; Dorieux, Flávia W C; Scarante, Franciele F; Ilkiw, Jessica L; Louzada, Fernando M; Chowdhury, Namrata R; van der Veen, Daan R; Middleton, Benita; Pennings, Jeroen L A; Swann, Jonathan R; Skene, Debra J; Lima, Marcelo M S
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Open Access
Type
Article
Language
en
Date
2019-02-13
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Title
Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers.
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Sci Rep 2019; 9(1):1898
Abstract
Parkinson's disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key non-motor features of the disease. Increasing evidence of a possible association between sleep disruption and the neurodegenerative process suggests that sleep impairment could produce a detectable metabolic signature on the disease. In order to integrate neurocognitive and metabolic parameters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chronic sleep restriction (SR) (6 h/day for 21 days) condition. We found that SR combined with PD altered several behavioural (reversal of locomotor activity impairment; cognitive impairment; delay of rest-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylalanine, and lipoproteins, pointing to mitochondrial impairment). If combined, our results bring a plethora of parameters that represents reliable early-phase PD biomarkers which can easily be measured and could be translated to human studies.