Excretie van radioactiviteit in de gal en urine van de Riv:TOX rat na intraveneuze toediening van 14C-gelabeld benzo(a)pyreen en reabsorptie van radioactiviteit uit de gal
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Open Access
Type
Report
Language
nl
Date
1994-10-31
Research Projects
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Title
Excretie van radioactiviteit in de gal en urine van
de Riv:TOX rat na intraveneuze toediening van 14C-gelabeld benzo(a)pyreen en
reabsorptie van radioactiviteit uit de gal
Translated Title
Excretion of radioactivity in the bile and urine
of the Riv:TOX rat after intravenously of 14C-labelled benzo(a)pyrene and
reabsorption of radioactivity from the bile
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Abstract
Aan drie Riv:TOX ratten werd een intraveneus infuus van
14C-gelabeld benzo(a)pyreen toegediend in een dosering van 5 mg per kg
lichaamsgewicht. Er werden gedurende een periode van 7 uur monsters genomen
van bloed, gal en urine. De plasmaconcentratie van het 14C-radiolabel nam
toe tot ongeveer vier uur na toediening. Gedurende drie uur na toediening
werd ongeveer 11% van de dosis uitgescheiden in de gal, en ongeveer 0,3% in
de urine. Na toediening van de gal van deze ratten in het duodenum van drie
andere galganggecanuleer de ratten werd in zes uur ongeveer 17% van de
radioactiviteit opgenomen en weer uitgeschei den in de gal en urine (17% in
de gal en 0,5% in de urine). De cumulatieve excretie in de urine was
ongeveer 6% na vier dagen.
An infusion of 14C-labeled benzo(a)pyrene was administered over 35 minutes to three Riv:TOX rats, at a dose of 5 mg per kg bodyweight. Blood, bile en urine were sampled over a period up to 7 h. The plasma levels of the 14C-radiolabel increased up to four hours after administration. Within three hours after administration, about 11% of the dose was excreted in the bile, and about 0.3% in the urine. After intraduodenal administration of the bile from these rats to three other bileduct-cannulated rats, about 17% of the radioactivity was absorbed and excreted again in the bile and urine within six hours (17% in the bile and 0.5% in the urine). The cumulative excretion in the urine was about 6% in four days.
An infusion of 14C-labeled benzo(a)pyrene was administered over 35 minutes to three Riv:TOX rats, at a dose of 5 mg per kg bodyweight. Blood, bile en urine were sampled over a period up to 7 h. The plasma levels of the 14C-radiolabel increased up to four hours after administration. Within three hours after administration, about 11% of the dose was excreted in the bile, and about 0.3% in the urine. After intraduodenal administration of the bile from these rats to three other bileduct-cannulated rats, about 17% of the radioactivity was absorbed and excreted again in the bile and urine within six hours (17% in the bile and 0.5% in the urine). The cumulative excretion in the urine was about 6% in four days.
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