Epigenome-wide association study of adiposity and future risk of obesity-related diseases.
Campanella, Gianluca; Gunter, Marc J; Polidoro, Silvia; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Fiorito, Giovanni; Guarrera, Simonetta; Iacoviello, Licia; Bergdahl, Ingvar A; Melin, Beatrice; Lenner, Per; de Kok, Theo M C M; Georgiadis, Panagiotis; Kleinjans, Jos C S; Kyrtopoulos, Soterios A; Bueno-de-Mesquita, H Bas; Lillycrop, Karen A; May, Anne M; Onland-Moret, N Charlotte; Murray, Robert; Riboli, Elio; Verschuren, Monique; Lund, Eiliv; Mode, Nicolle; Sandanger, Torkjel M; Fiano, Valentina; Trevisan, Morena; Matullo, Giuseppe; Froguel, Philippe; Elliott, Paul; Vineis, Paolo; Chadeau-Hyam, Marc
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Series / Report no.
Open Access
Type
Article
Language
en
Date
2018-05-01
Research Projects
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Journal Issue
Title
Epigenome-wide association study of adiposity and future risk of obesity-related diseases.
Translated Title
Published in
Int J Obes 2018; advance online publication (ahead of print)
Abstract
Obesity is an established risk factor for several common chronic diseases such as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the biological basis for these relationships is not fully understood. To explore the association of obesity with these conditions, we investigated peripheral blood leucocyte (PBL) DNA methylation markers for adiposity and their contribution to risk of incident breast and colorectal cancer and myocardial infarction.