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Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains
Sabat, Artur Melles, Damian C Martirosian, Gayane Grundmann, Hajo van Belkum, Alex Hryniewicz, Waleria
Sabat, Artur
Melles, Damian C
Martirosian, Gayane
Grundmann, Hajo
van Belkum, Alex
Hryniewicz, Waleria
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Open Access
Type
Article
Language
en
Date of publication
2006-03-01
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Title
Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains
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Abstract
The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.