Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.
O'Keefe, James H Tintle, Nathan L Harris, William S O'Keefe, Evan L Sala-Vila, Aleix Attia, John Garg, G Manohar Hure, Alexis Bork, Christian Sørensen Schmidt, Erik Berg
O'Keefe, James H
Tintle, Nathan L
Harris, William S
O'Keefe, Evan L
Sala-Vila, Aleix
Attia, John
Garg, G Manohar
Hure, Alexis
Bork, Christian Sørensen
Schmidt, Erik Berg
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2023-12-22
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.
Translated Title
Published in
Stroke 2024;55(1):50-58
Abstract
Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.