Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study.
Cole-Hunter, Thomas; Zhang, Jiawei; So, Rina; Samoli, Evangelia; Liu, Shuo; Chen, Jie; Strak, Maciej; Wolf, Kathrin; Weinmayr, Gudrun; Rodopolou, Sophia; Remfry, Elizabeth; de Hoogh, Kees; Bellander, Tom; Brandt, Jørgen; Concin, Hans; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hoffmann, Barbara; Hvidtfeldt, Ulla A; Jöckel, Karl-Heinz; Mortensen, Laust H; Ketzel, Matthias; Yacamán Méndez, Diego; Leander, Karin; Ljungman, Petter; Faure, Elodie; Lee, Pei-Chen; Elbaz, Alexis; Magnusson, Patrik K E; Nagel, Gabriele; Pershagen, Göran; Peters, Annette; Rizzuto, Debora; Vermeulen, Roel C H; Schramm, Sara; Stafoggia, Massimo; Katsouyanni, Klea; Brunekreef, Bert; Hoek, Gerard; Lim, Youn-Hee; Andersen, Zorana J
Citations
Altmetric:
Series / Report no.
Open Access
Type
Article
Language
en
Date
2022-11-30
Research Projects
Organizational Units
Journal Issue
Title
Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study.
Translated Title
Published in
Environment international 2022;171:107667
Abstract
Within the project 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders.