Tetrahydrobiopterine als mogelijke mediator in septische shock
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Series / Report no.
Open Access
Type
Report
Language
nl
Date
1994-01-31
Research Projects
Organizational Units
Journal Issue
Title
Tetrahydrobiopterine als mogelijke mediator in septische shock
Translated Title
[Tetrahydrobiopterin as putative mediator in septic shock.]
Published in
Abstract
Enhanced serum levels neopterin are associated with various immune-related diseases like septic shock and vascular leakage syndrome. Tetrahydrobiopterin (THB, 100 muM) but not bioterin induces appreciable endothelium-dependent vasodilatation and enhances cGMP-level (95% increase) to the same extent as arecoline. NG-methyl-L-arginine (L-NAME) does not antagonize the tetrahydrobiopterin effects. In addition, tetrahydrobiopterin enhances cGMP-level in tracheal smooth muscle (+28%) and artery pulmonalis (+57%). Present results show that tetrahydrobiopterin being precursor of biopterin and co-factor of NO-synthase, induces vasodilatation by increasing intracellular cyclic GMP level and suggest a prominent role for tetrahydrobiopterin in immune-triggered hypotension.<br>
Description
Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
GHI