Maximum permissible concentrations and negligible concentrations for phthalates (dibutylphthalate and di(2-ethylhexyl)phthlate), with emphasis on endocrine disruptive properties
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Series / Report no.
Open Access
Type
Report
Language
en
Date
1999-07-31
Research Projects
Organizational Units
Journal Issue
Title
Maximum permissible concentrations and negligible
concentrations for phthalates (dibutylphthalate and
di(2-ethylhexyl)phthlate), with emphasis on endocrine disruptive
properties
Translated Title
Maximaal toelaatbare risiconiveaus en
verwaarloosbare risiconiveaus voor ftalaten
Published in
Abstract
In dit rapport zijn maximaal toelaatbare risiconiveaus
(MTRs) en verwaarloosbare risiconiveaus (VRs) afgeleid voor dibutylftalaat
en di-ethylhexyl-ftalaat. Ftalaten worden vaak verdacht van endocriene
verstoring. Gegevens over endocriene en reproductieve verstoring door
ftalaten zijn verzameld van in vitro en in vivo testen. Met name de
twee-generatie reproductie studies blijken gevoelig om endocrien verstorende
effecten te signaleren. Geen enkele van de testen met uterien gewicht als
eindpunt (vaak in combinatie met vaginale cornificatie gemeten) liet
positieve resultaten zien. Op basis van de beschikbare data is
geconcludeerd dat de MTRs die afgeleid zijn op basis van klassiek gebruikte
eindpunten (overleving, groei en reproductie) voor de geteste verbindingen
voldoende bescherming bieden tegen endocrien verstorende
effecten.
This report presents maximal permissible concentrations (MPCs) and negligible concentrations (NCs) are derived for di-n-butylphthalate (DBP) and di(2-ethylhexyl)phthalate (DEHP). Phthalates are often mentioned as suspected endocrine disrupters. Data with endpoints related to the endocrine or reproductive system for in vitro as well as in vivo tests were collected. Especially the two-generation reproduction studies were found sensitive in detecting endocrine disruptive effects. None of the tests with uterine weight (often in combination with vaginal cornification) showed positive results. The most sensitive endpoints in the in vivo studies are converted to concentrations in the organic carbon exerting adverse effects. Based on the available data, the MPCs derived using classical endpoints (survival, growth and reproduction) are concluded to give sufficient protection against adverse endocrine disruptive effects.
This report presents maximal permissible concentrations (MPCs) and negligible concentrations (NCs) are derived for di-n-butylphthalate (DBP) and di(2-ethylhexyl)phthalate (DEHP). Phthalates are often mentioned as suspected endocrine disrupters. Data with endpoints related to the endocrine or reproductive system for in vitro as well as in vivo tests were collected. Especially the two-generation reproduction studies were found sensitive in detecting endocrine disruptive effects. None of the tests with uterine weight (often in combination with vaginal cornification) showed positive results. The most sensitive endpoints in the in vivo studies are converted to concentrations in the organic carbon exerting adverse effects. Based on the available data, the MPCs derived using classical endpoints (survival, growth and reproduction) are concluded to give sufficient protection against adverse endocrine disruptive effects.
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