Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024
Linkevicius, Marius Alm, Erik Roer, Louise Svartström, Olov Dada-Olorunwa, Maria Räisänen, Kati Reichert, Felix Möller, Sophie Clarke, Christina Cormican, Martin
Linkevicius, Marius
Alm, Erik
Roer, Louise
Svartström, Olov
Dada-Olorunwa, Maria
Räisänen, Kati
Reichert, Felix
Möller, Sophie
Clarke, Christina
Cormican, Martin
Series / Report no.
Open Access
Type
Journal Article
Article
Article
Language
en
Date of publication
2025-07-10
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024
Translated Title
Published in
Euro Surveill 2025; 30(27):2500439
Abstract
An investigation of the European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) detected the same mosaic IncHI1B(pNDM-MAR) resistance (OXA-48) and virulence (aerobactin) plasmid in 492 isolates from eight European Union countries during 2019-2024. Involvement of various sequence types (STs), multiple introductions, followed by large clonal outbreaks of three STs (ST147, ST392, ST45) carrying the plasmid in two countries indicate a high risk for further spread of this plasmid and a potential for difficult-to-treat infections to rise.