Comparative risk assessment of radiation and other mutagenic agents. Low dose relative risk of different ionizing radiations and comparison with UV-radiation
Leenhouts HP Chadwick KH Pruppers MJM Wijngaard E Sijsma MJ Bouwens BT
Leenhouts HP
Chadwick KH
Pruppers MJM
Wijngaard E
Sijsma MJ
Bouwens BT
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Series / Report no.
Open Access
Type
Report
Language
en
Date of publication
1990-04-30
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Comparative risk assessment of radiation and other mutagenic agents. Low dose relative risk of different ionizing radiations and comparison with UV-radiation
Translated Title
Risicovergelijking van straling en andere mutagene stoffen. Het relatieve risico bij lage doses van verschillende soorten ioniserende straling en de vergelijking met UV-straling
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Abstract
This report is the final report of a research contract of RIVM in the framework of the Radiation Protection Programme of the Commission of the European Communities. The aim of the project was to investigate the nature of the dose-effect relationship for radiobiological effects after different types of ionizing radiation and UV. The results of the contract support the idea that the linear-quadratic dose relationship for radiobiological effects does reflect a two-hit or two-event type of radiation effect. The track structure calculations of the linear term indicate that the DNA double-strand break could be the crucial lesion and that the two simultaneous events should occur close to each strand of the DNA molecule in a single track. The experimental data indicate that the quadratic term arises from the combination of two time independently induced events the role of which can be modified by repair but these data do not provide any information on the nature of the radiation induced lesions.<br>
Description
Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
EG/DG12