A prioritization strategy for functional alternatives to bisphenol A in food contact materials
van den Brand, Annick D Hessel, Ellen VS Rijk, Rinus van de Ven, Bianca Leijten, Niels M Rorije, Emiel den Braver-Sewradj, Shalenie P
van den Brand, Annick D
Hessel, Ellen VS
Rijk, Rinus
van de Ven, Bianca
Leijten, Niels M
Rorije, Emiel
den Braver-Sewradj, Shalenie P
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Open Access
Type
Article
Language
en
Date of publication
2024-05-10
Year of publication
Research Projects
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Journal Issue
Title
A prioritization strategy for functional alternatives to bisphenol A in food contact materials
Translated Title
Published in
Crit Rev Toxicol 2024; 54(5):291-314
Abstract
The use of bisphenol A (BPA), a substance of very high concern, is proposed to be banned in food contact materials (FCMs) in the European Union. To prevent regrettable substitution of BPA by alternatives with similar or unknown hazardous properties, it is of importance to gain the relevant toxicological information on potential BPA alternative substances and monitor them adequately. We created an inventory of over 300 substances mentioned as potential BPA alternatives in regulatory reports and scientific literature. This study presents a prioritization strategy to identify substances that may be used as an alternative to BPA in FCMs. We prioritized 20 potential BPA alternatives of which 10 are less familiar. We subsequently reviewed the available information on the 10 prioritized less familiar substances regarding hazard profiles and migration potential obtained from scientific literature and in silico screening tools to identify a possible risk of the substances. Major data gaps regarding the hazard profiles of the prioritized substances exist, although the scarce available data give some indications on the possible hazard for some of the substances (like bisphenol TMC, 4,4-dihydroxybenzophenone, and tetrachlorobisphenol A). In addition, very little is known about the actual use and exposure to these substances. More toxicological research and monitoring of these substances in FCMs are, therefore, required to avoid regrettable substitution of BPA in FCM.