Fecal Microbiota Transplantation Influences Procarcinogenic Escherichia coli in Recipient Recurrent Clostridioides difficile Patients.
Nooij, Sam Ducarmon, Quinten R Laros, Jeroen F J Zwittink, Romy D Norman, Jason M Smits, Wiep Klaas Verspaget, Hein W Keller, Josbert J Terveer, Elisabeth M Kuijper, Ed J
Nooij, Sam
Ducarmon, Quinten R
Laros, Jeroen F J
Zwittink, Romy D
Norman, Jason M
Smits, Wiep Klaas
Verspaget, Hein W
Keller, Josbert J
Terveer, Elisabeth M
Kuijper, Ed J
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2021-06-11
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Fecal Microbiota Transplantation Influences Procarcinogenic Escherichia coli in Recipient Recurrent Clostridioides difficile Patients.
Translated Title
Published in
Gastroenterology 2021; 161(4):1218-28
Abstract
Patients with multiple recurrent Clostridioides difficile infection (rCDI) have a disturbed gut microbiota that can be restored by fecal microbiota transplantation (FMT). Despite extensive screening, healthy feces donors may carry bacteria in their intestinal tract that could have long-term health effects, such as potentially procarcinogenic polyketide synthase-positive (pks+) Escherichia coli. Here, we aim to determine whether the pks abundance and persistence of pks+E coli is influenced by pks status of the donor feces.