Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Gaziano, Liam; Sun, Luanluan; Arnold, Matthew; Bell, Steven; Cho, Kelly; Kaptoge, Stephen K; Song, Rebecca J; Burgess, Stephen; Posner, Daniel C; Mosconi, Katja; Robinson-Cohen, Cassianne; Mason, Amy M; Bolton, Thomas R; Tao, Ran; Allara, Elias; Schubert, Petra; Chen, Lingyan; Staley, James R; Staplin, Natalie; Altay, Servet; Amiano, Pilar; Arndt, Volker; Ärnlöv, Johan; Barr, Elizabeth LM; Björkelund, Cecilia; Boer, Jolanda M A; Brenner, Hermann; Casiglia, Edoardo; Chiodini, Paolo; Cooper, Jackie A; Coresh, Josef; Cushman, Mary; Dankner, Rachel; Davidson, Karina W; de Jongh, Renate T; Donfrancesco, Chiara; Engström, Gunnar; Freisling, Heinz; de la Cámara, Agustín Gómez; Gudnason, Vilmundur; Hankey, Graeme J; Hansson, Per-Olof; Heath, Alicia K; Hoorn, Ewout J; Imano, Hironori; Jassal, Simerjot K; Kaaks, Rudolf; Katzke, Verena; Kauhanen, Jussi; Kiechl, Stefan; Koenig, Wolfgang; Kronmal, Richard A; Kyrø, Cecilie; Lawlor, Deborah A; Ljungberg, Börje; MacDonald, Conor; Masala, Giovanna; Meisinger, Christa; Melander, Olle; Moreno Iribas, Conchi; Ninomiya, Toshiharu; Nitsch, Dorothea; Nordestgaard, Børge G; Onland-Moret, Charlotte; Palmieri, Luigi; Petrova, Dafina; Garcia, Jose Ramón Quirós; Rosengren, Annika; Sacerdote, Carlotta; Sakurai, Masaru; Santiuste, Carmen; Schulze, Matthias B; Sieri, Sabina; Sundström, Johan; Tikhonoff, Valérie; Tjønneland, Anne; Tong, Tammy; Tumino, Rosario; Tzoulaki, Ioanna; van der Schouw, Yvonne T; Verschuren, WM Monique; Völzke, Henry; Wallace, Robert B; Wannamethee, S Goya; Weiderpass, Elisabete; Willeit, Peter; Woodward, Mark; Yamagishi, Kazumasa; Zamora-Ros, Raul; Akwo, Elvis A; Pyarajan, Saiju; Gagnon, David R; Tsao, Philip S; Muralidhar, Sumitra; Edwards, Todd L; Damrauer, Scott M; Joseph, Jacob; Pennells, Lisa; Wilson, Peter WF; Harrison, Seamus; Gaziano, Thomas A; Inouye, Michael; Baigent, Colin; Casas, Juan P; Langenberg, Claudia; Wareham, Nick; Riboli, Elio; Gaziano, J Michael; Danesh, John; Hung, Adriana M; Butterworth, Adam S; Wood, Angela M; Di Angelantonio, Emanuele
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Open Access
Type
Article
Language
en
Date
2022-10-31
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Title
Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Translated Title
Published in
Circulation 2022;146(20):1507-17
Abstract
There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD.