Effects of subchronic dietary exposure to the engineered nanomaterials SiO and CeO in C57BL/6J and 5xFAD Alzheimer model mice.
Sofranko, Adriana Wahle, Tina Kolling, Julia Heusinkveld, Harm J Stahlmecke, Burkhard Rosenbruch, Martin Albrecht, Catrin Schins, Roel P F
Sofranko, Adriana
Wahle, Tina
Kolling, Julia
Heusinkveld, Harm J
Stahlmecke, Burkhard
Rosenbruch, Martin
Albrecht, Catrin
Schins, Roel P F
Citations
Altmetric:
Series / Report no.
Open Access
Type
Article
Other
Other
Language
en
Date of publication
2022-03-25
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Effects of subchronic dietary exposure to the engineered nanomaterials SiO and CeO in C57BL/6J and 5xFAD Alzheimer model mice.
Translated Title
Published in
Part Fibre Toxicol 2022;19(1):23
Abstract
There is an increasing concern about the neurotoxicity of engineered nanomaterials (NMs). To investigate the effects of subchronic oral exposures to SiO2 and CeO2 NMs on Alzheimer's disease (AD)-like pathology, 5xFAD transgenic mice and their C57BL/6J littermates were fed ad libitum for 3 or 14 weeks with control food pellets, or pellets dosed with these respective NMs at 0.1% or 1% (w/w). Behaviour effects were evaluated by X-maze, string suspension, balance beam and open field tests. Brains were analysed for plaque load, beta-amyloid peptide levels, markers of oxidative stress and neuroinflammation.