Exploring Structural Uncertainty and Impact of Health State Utility Values on Lifetime Outcomes in Diabetes Economic Simulation Models: Findings from the Ninth Mount Hood Diabetes Quality-of-Life Challenge.
Tew, Michelle; Willis, Michael; Asseburg, Christian; Bennett, Hayley; Brennan, Alan; Feenstra, Talitha; Gahn, James; Gray, Alastair; Heathcote, Laura; Herman, William H; Isaman, Deanna; Kuo, Shihchen; Lamotte, Mark; Leal, José; McEwan, Phil; Nilsson, Andreas; Palmer, Andrew J; Patel, Rishi; Pollard, Daniel; Ramos, Mafalda; Sailer, Fabian; Schramm, Wendelin; Shao, Hui; Shi, Lizheng; Si, Lei; Smolen, Harry J; Thomas, Chloe; Tran-Duy, An; Yang, Chunting; Ye, Wen; Yu, Xueting; Zhang, Ping; Clarke, Philip
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Type
Article
Language
en
Date
2021-12-15
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Title
Exploring Structural Uncertainty and Impact of Health State Utility Values on Lifetime Outcomes in Diabetes Economic Simulation Models: Findings from the Ninth Mount Hood Diabetes Quality-of-Life Challenge.
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Med Decis Making 2022; 42(5):599-611
Abstract
Substantial cross-model variability in incremental LYs and QALYs was observed, particularly for HbA1c and body mass index (BMI) intervention profiles. For a 0.5%-point permanent HbA1c reduction, LY gains ranged from 0.050 to 0.750. For a 1-unit permanent BMI reduction, incremental QALYs varied from a small decrease in QALYs (-0.024) to an increase of 0.203. Changes in utility values of health states had a much smaller impact (to the hundredth of a decimal place) on incremental QALYs. Microsimulation models were found to generate a mean of 3.41 more LYs than cohort simulation models (P = 0.049).