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Immunogenicity of pneumococcal vaccination in HIV infected individuals: A systematic review and meta-analysis.
Garrido, Hannah M Garcia Schnyder, Jenny L Tanck, Michael W T Vollaard, Albert Spijker, René Grobusch, Martin P Goorhuis, Abraham
Garrido, Hannah M Garcia
Schnyder, Jenny L
Tanck, Michael W T
Vollaard, Albert
Spijker, René
Grobusch, Martin P
Goorhuis, Abraham
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2020-11-23
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Immunogenicity of pneumococcal vaccination in HIV infected individuals: A systematic review and meta-analysis.
Translated Title
Published in
EClinicalMedicine 2020; 29-30:100576
Abstract
The systematic review protocol was published online (PROSPERO ID: CRD 42020153137). We searched Medline (Ovid), EMBASE (Ovid), and the Global Health Library for publications from 2000 to June 11, 2020. We included all studies in adult PLWH that reported vaccine immunogenicity outcomes. The primary outcome was seroconversion rate (SCR) after PCV, PPSV and PCV/PPSV combined. For random-effects meta-analysis, we included studies defining SCR as a ≥ 2-fold increase in IgG from baseline, and reporting SCR for serotypes 6B, 14, or overall SCR, 1-3 months after vaccination.