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Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.
Pasanen, Anu Karjalainen, Minna K Bont, Louis Piippo-Savolainen, Eija Ruotsalainen, Marja Goksƶr, Emma Kumawat, Kuldeep Hodemaekers, Hennie Nuolivirta, Kirsi Jartti, Tuomas
Pasanen, Anu
Karjalainen, Minna K
Bont, Louis
Piippo-Savolainen, Eija
Ruotsalainen, Marja
Goksƶr, Emma
Kumawat, Kuldeep
Hodemaekers, Hennie
Nuolivirta, Kirsi
Jartti, Tuomas
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Open Access
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Article
Language
en
Date of publication
2017-01-31
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srep41653.pdf
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Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.
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Sci Rep 2017; 7:41653
Abstract
Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish-Swedish population of 217 children hospitalized for bronchiolitis and 778 controls. The most promising SNPs (nā=ā77) were genotyped in a Dutch replication population of 416 cases and 432 controls. Finally, we used a set of 202 Finnish bronchiolitis cases to further investigate candidate SNPs. We did not detect genome-wide significant associations, but several suggestive association signals (pā<ā10-5) were observed in the GWAS. In the replication population, three SNPs were nominally associated (pā<ā0.05). Of them, rs269094 was an expression quantitative trait locus (eQTL) for KCND3, previously shown to be associated with occupational asthma. In the additional set of Finnish cases, the association for another SNP (rs9591920) within a noncoding RNA locus was further strengthened. Our results provide a first genome-wide examination of the genetics underlying bronchiolitis. These preliminary findings require further validation in a larger sample size.