Long-Term Exposure to Source-Specific Fine Particles and Mortality─A Pooled Analysis of 14 European Cohorts within the ELAPSE Project.
Chen, Jie Hoek, Gerard de Hoogh, Kees Rodopoulou, Sophia Andersen, Zorana J Bellander, Tom Brandt, Jørgen Fecht, Daniela Forastiere, Francesco Gulliver, John
Chen, Jie
Hoek, Gerard
de Hoogh, Kees
Rodopoulou, Sophia
Andersen, Zorana J
Bellander, Tom
Brandt, Jørgen
Fecht, Daniela
Forastiere, Francesco
Gulliver, John
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2022-06-23
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Long-Term Exposure to Source-Specific Fine Particles and Mortality─A Pooled Analysis of 14 European Cohorts within the ELAPSE Project.
Translated Title
Published in
Environmental science & technology 2022; 56(13):9277-9290
Abstract
We assessed mortality risks associated with source-specific fine particles (PM2.5) in a pooled European cohort of 323,782 participants. Cox proportional hazard models were applied to estimate mortality hazard ratios (HRs) for source-specific PM2.5 identified through a source apportionment analysis. Exposure to 2010 annual average concentrations of source-specific PM2.5 components was assessed at baseline residential addresses. The source apportionment resulted in the identification of five sources: traffic, residual oil combustion, soil, biomass and agriculture, and industry. In single-source analysis, all identified sources were significantly positively associated with increased natural mortality risks. In multisource analysis, associations with all sources attenuated but remained statistically significant with traffic, oil, and biomass and agriculture. The highest association per interquartile increase was observed for the traffic component (HR: 1.06; 95% CI: 1.04 and 1.08 per 2.86 μg/m3 increase) across five identified sources. On a 1 μg/m3 basis, the residual oil-related PM2.5 had the strongest association (HR: 1.13; 95% CI: 1.05 and 1.22), which was substantially higher than that for generic PM2.5 mass, suggesting that past estimates using the generic PM2.5 exposure response function have underestimated the potential clean air health benefits of reducing fossil-fuel combustion. Source-specific associations with cause-specific mortality were in general consistent with findings of natural mortality.