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Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
van Duijnhoven, Fränzel J B Jenab, Mazda Hveem, Kristian Siersema, Peter D Fedirko, Veronika Duell, Eric J Kampman, Ellen Halfweeg, Anouk van Kranen, Henk J van den Ouweland, Jody M W
van Duijnhoven, Fränzel J B
Jenab, Mazda
Hveem, Kristian
Siersema, Peter D
Fedirko, Veronika
Duell, Eric J
Kampman, Ellen
Halfweeg, Anouk
van Kranen, Henk J
van den Ouweland, Jody M W
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018-03-15
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
Translated Title
Published in
Int J Cancer 2018; 142(6):1189-1201
Abstract
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2and 25(OH)D3combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.