Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults
Cordova, R Knaze, V Viallon, V Rust, P Schalkwijk, CG Weiderpass, E Wagner, K-H Mayen-Chacon, A-L Aglago, EK Dahm, CC
Cordova, R
Knaze, V
Viallon, V
Rust, P
Schalkwijk, CG
Weiderpass, E
Wagner, K-H
Mayen-Chacon, A-L
Aglago, EK
Dahm, CC
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2019-11-07
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults
Translated Title
Published in
Eur J Nutr 2020: 59(7):2893-904
Abstract
A total of 255,170 participants aged 25-70 years were recruited in ten European countries (1992-2000) in the PANACEA study (Physical Activity, Nutrition, Alcohol, Cessation of smoking, Eating out of home in relation to Anthropometry), a sub-cohort of the EPIC (European Prospective Investigation into Cancer and Nutrition). Body weight was measured at recruitment and self-reported between 2 and 11 years later depending on the study center. A reference database for AGEs was used containing UPLC-MS/MS-measured Nε-(carboxymethyl)-lysine (CML), Nε-(1-carboxyethyl)-lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) in 200 common European foods. This reference database was matched to foods and decomposed recipes obtained from country-specific validated dietary questionnaires in EPIC and intake levels of CEL, CML, and MG-H1 were estimated. Associations between dietary AGEs intake and body weight change were estimated separately for each of the three AGEs using multilevel mixed linear regression models with center as random effect and dietary AGEs intake and relevant confounders as fixed effects.