Near-field and far-field exposures to radiofrequency electromagnetic fields and cancer risks in humans: a protocol for an umbrella review of epidemiological studies
Ziegler, Joshua Louis Lagorio, Susanna Mattsson, Mats-Olof Zeni, Olga Bolte, John Ledent, Maryse Velghe, Maarten Stam, Rianne Rijs, Kelly Deltour, Isabelle
Ziegler, Joshua Louis
Lagorio, Susanna
Mattsson, Mats-Olof
Zeni, Olga
Bolte, John
Ledent, Maryse
Velghe, Maarten
Stam, Rianne
Rijs, Kelly
Deltour, Isabelle
Series / Report no.
Open Access
Type
Journal Article
Article
Article
Language
en
Date of publication
2026-03-12
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Near-field and far-field exposures to radiofrequency electromagnetic fields and cancer risks in humans: a protocol for an umbrella review of epidemiological studies
Translated Title
Published in
Syst Rev 2026; 15(1):130
Abstract
BACKGROUND: Exposure to radiofrequency electromagnetic fields (RF-EMF; frequencies 100 kHz to 300 GHz) is ubiquitous. As the use of RF-EMF has grown steadily since the 1950s due to advances in telecommunications and other technologies, concerns about potential health effects have persisted. The World Health Organization (WHO) identified key areas of concern, with cancer being most frequently rated as critical. To synthesize evidence on the association between RF-EMF exposure and neoplastic diseases, we will carry out two separate umbrella reviews to account for different RF-EMF exposure conditions: one will focus on near-field exposure and the other on far-field exposure. Both umbrella reviews will include RF-EMF exposure in living and occupational settings.
METHODS: Systematic reviews and meta-analyses of human observational studies on RF-EMF and cancer were searched in MEDLINE, Web of Science Core Collection, EMF-Portal, and Epistemonikos databases. Eligibility criteria will follow the PECOS (Population, Exposure, Comparator, Outcome, Study type) scheme. Eligibility and quality of the identified articles will be evaluated by two reviewers independently. The tools AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews) and ROBIS (Risk of Bias in Systematic Reviews) will be used to systematically assess methodological quality and risk of bias. Data will be extracted and summarized in a qualitative synthesis using standardized forms and presented in text and tables.
DISCUSSION: These umbrella reviews aim to offer a comprehensive overview of the topic by including systematic reviews and meta-analyses that studied cancer-related health effects of near-field and far-field RF-EMF exposure. In addition, a risk of bias rating will be performed to assess the quality of existing systematic reviews and meta-analyses in the field.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42024529007.