Species-Specific Patterns of Gut Metabolic Modules in Dutch Individuals with Different Dietary Habits.
Shetty, Sudarshan A Stege, Paul B Hordijk, Joost Gijsbers, Esther Dierikx, Cindy M van Duijkeren, Engeline Franz, Eelco Willems, Rob J L Paganelli, Fernanda L Fuentes, Susana
Shetty, Sudarshan A
Stege, Paul B
Hordijk, Joost
Gijsbers, Esther
Dierikx, Cindy M
van Duijkeren, Engeline
Franz, Eelco
Willems, Rob J L
Paganelli, Fernanda L
Fuentes, Susana
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2022-11-17
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Species-Specific Patterns of Gut Metabolic Modules in Dutch Individuals with Different Dietary Habits.
Translated Title
Published in
mSphere 2022; 7(6):e0051222
Abstract
Diet is an important determinant of the human gut microbiome. Here, we analyzed fecal metagenomes of Dutch adults following omnivorous, pescatarian, vegan, and vegetarian diets. We compared the taxonomic composition of individuals from our study with publicly available gut metagenomes from westernized and non-westernized societies. We observed that, despite long-term transition to diets rich in plant fibers (vegan or vegetarian), the microbiomes of these were typical of westernized populations, and similar in composition to omnivores. Although there were no major differences in metabolic modules, we identified differences in the species that contributed to particular functions, such as carbohydrate degradation and short-chain fatty acid metabolism. Overall, this study shows functional redundancy of the microbiomes among westernized populations, which is independent of long-term individual dietary habits. IMPORTANCE Diet is an important modulator of the human gut microbiome, which is susceptible to increased consumption of plant fibers in vegan or vegetarian lifestyles. To investigate this, we compared the gut microbiome of Dutch adults following omnivorous, pescatarian, vegan and vegetarian diets. We did not observe major differences in the gut microbiome composition and function between individuals with different dietary habits. However, we observed differences in the species that contribute to the core functions of the gut microbiome. Our study thus emphasizes the need to better understand the species-specific functional changes associated with dietary habits in the human gut microbiome.