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Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner.
Rousseau-Ralliard, Delphine; Richard, Christophe; Hoarau, Pauline; Lallemand, Marie-Sylvie; Morillon, Lucie; Aubrière, Marie-Christine; Valentino, Sarah A; Dahirel, Michèle; Guinot, Marine; Fournier, Natalie; Morin, Gwendoline; Mourier, Eve; Camous, Sylvaine; Slama, Rémy; Cassee, Flemming R; Couturier-Tarrade, Anne; Chavatte-Palmer, Pascale
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Open Access
Type
Article
Language
en
Date
2021-07-14
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Title
Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner.
Translated Title
Published in
Environ Res 2021; 200:111690
Abstract
The protocol was designed to mimic human exposure in large European cities. Females rabbits were exposed to diluted (1 mg/m3) DE (exposed, n = 9) or clean air (controls, n = 7), from 3 days after mating, 2 h/d and 5 d/wk in a nose-only inhalation system throughout gestation (gestation days 3-27). After birth and weaning, 72 offspring (47 exposed and 25 controls) were raised until adulthood (7.5 months) to evaluate their cardio-metabolic status, including the monitoring of body weight and food intake, fasting biochemistry, body composition (iDXA), cardiovascular parameters and glucose tolerance. After a metabolic challenge (high fat diet in males and gestation in females), animals were euthanized for postmortem phenotyping.