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    Developments in infants exposure to dioxins, furans and PCBs and potential health consequences in the Netherlands

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    Authors
    Cuijpers CEJ
    Zeilmaker MJ
    Molen GW van der
    Slob W
    Lebret E
    Series/Report no.
    RIVM rapport 529102007
    Type
    Report
    Language
    en
    
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    Title
    Developments in infants exposure to dioxins, furans and PCBs and potential health consequences in the Netherlands
    Translated Title
    Ontwikkelingen in de blootstelling van zuigelingen aan dioxinen, furanen en PCBs en potentiele gezondheidsrisico's, in Nederland
    Publiekssamenvatting
    This report describes the evaluation of the time trend by means of PBPK modelling, and the associated health effects of pre- and postnatal exposure of infants to dioxins, furans and PCBs. Using PBPK modelling there was an expected decrease of ca. 20% in dioxin levels in human milk shown for 1998 compared to 1993. Evaluation of the epidemiological literature resulted in critical remarks on the exposure characterisation and the data analyses of the studies. Lack of convincing exposure-response relationships meant that no quantitative assessment of the associated health risk in infants could be performed. Pooled and/or re-analysis of the existing data could shed some light on the apparant inconsistencies reported so far.
    De tijdtrends (m.b.v. PBPK modellering) en geassocieerde gezondheidseffecten, van pre- en postnatale blootstelling van zuigelingen aan dioxinen, furanen en PCBs werden ge-evalueerd. Op basis van de PBPK modellering wordt in 1998 een daling van ca. 20% in de dioxine gehalten in moedermelk verwacht, ten opzichte van 1993. In de evaluatie van de epidemiologische onderzoeken worden een aantal kritische kant-tekeningen geplaatst bij de blootstellingskarakterisering en de data-analyse van de studies. Door het ontbreken van duidelijke blootstellings-respons relaties kan geen kwantitatieve schatting van het gezondheidsrisico voor zuigelingen worden uitgevoerd. Gepoolde en/of her-analyse van de bestaande data zouden meer inzicht kunnen geven in de inconsistenties in de tot nu toe gerapporteerde data.
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    URI
    http://hdl.handle.net/10029/10096
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