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dc.contributor.authorBlok-Tip, L
dc.contributor.authorZomer, B
dc.contributor.authorBakker, F
dc.contributor.authorHartog, K D
dc.contributor.authorHamzink, M
dc.contributor.authorHove, J ten
dc.contributor.authorVredenbregt, M
dc.contributor.authorKaste, D de
dc.date.accessioned2007-04-25T07:42:36Z
dc.date.available2007-04-25T07:42:36Z
dc.date.issued2004-08-01
dc.identifier.citationFood Addit Contam 2004, 21(8):737-48en
dc.identifier.issn0265-203X
dc.identifier.pmid15370823
dc.identifier.doi10.1080/02652030412331272467
dc.identifier.urihttp://hdl.handle.net/10029/11381
dc.description.abstractThe structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance. Compounds 1-3 were identified as sildenafil analogues, 1 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine, and an acetyl group instead of the sulfonyl group, named acetildenafil, 2 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine (homosildenafil), and 3 bearing an N-hydroxylethylpiperazine moiety instead of an N-methylpiperazine, named hydroxyhomosildenafil. When analysing products marketed for penile erectile dysfunction or marketed as aphrodisiacs, attention should be given to the possible presence of these components.
dc.format.extent168037 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.titleStructure elucidation of sildenafil analogues in herbal products.en
dc.typeArticleen
dc.format.digYES
refterms.dateFOA2018-12-18T09:42:09Z
html.description.abstractThe structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance. Compounds 1-3 were identified as sildenafil analogues, 1 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine, and an acetyl group instead of the sulfonyl group, named acetildenafil, 2 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine (homosildenafil), and 3 bearing an N-hydroxylethylpiperazine moiety instead of an N-methylpiperazine, named hydroxyhomosildenafil. When analysing products marketed for penile erectile dysfunction or marketed as aphrodisiacs, attention should be given to the possible presence of these components.


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