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Prediction of environmental degradation rates for High Production Volume Chemicals (HPVC) using Quantitative Structure-Activity RelationshipsEstimates of (bio)degradation kinetics for 1073 compounds in various environmental compartments have been made as a part of the EU-project 'Fate and Activity Modelling of Environmental Pollutants using Structure-Activity Relationships' (FAME). These estimates have been made for all single compounds on the High Production Volume Chemicals (HPVC) list of the European Union (as of June 4th 1995). No predictions can be made for the large amount (> 50 %) of mixtures and ill-defined compounds on the HPVC-list. The models that have been applied are Quantitative Structure-Activity Relationships (QSARs), which were selected from literature. An indication of the precision of the estimates is given, either based on available validation studies of the models, and/or based on the statistical quality of the models. Given the large amount of compounds for which no or very few experimental degradation kinetics are available, these estimates can serve as supplementary information for the priority setting and the risk assessment of existing chemicals in the EU that is now being performed as a part of EU Regulation (EEC) 793/93 on existing chemical substances. In the future the estimates, and therefore the selected QSAR models, will be validated using new data on the HPVC that are being collected by the EU at this moment, from the European industries.