• Study to investigate the difference in reaction to intracutaneously and orally administered histamine between suspected histamine-intolerant patients and healthy volunteers

      den Broeder E; Kortboyer JM; Koers WJ; Bruijnzeel-Koomen CAFM; de Haan-Brand A; Wolthers BG; Breukelman H; Meulenbelt J; NVIC; ARO; afdeling Dermatologie en Allergologie (Academisch Ziekenhuis Utrecht); afdeling KCSB (Academisch Ziekenhuis Groningen) (Rijksinstituut voor Volksgezondheid en Milieu RIVM, 1996-04-30)
      A study, designed as a double-blind placebo controlled comparative study, has been performed in order to investigate the difference in reaction to intracutaneously and orally administered histamine between patients and healthy volunteers based on the assumption that histamine-intolerant patients have a relative shortage of the enzyme diamine-oxidase (DAO). Several parameters were determined in patients and compared to those in healthy volunteers. No statistical significant differences were found between patients and healthy volunteers after intracutaneous and oral administration of histamine. It can, therefore, be concluded that neither intracutaneous nor oral administration of histamine can as yet be used as a valid test to diagnose histamine-intolerance.<br>