• Developments in infants exposure to dioxins, furans and PCBs and potential health consequences in the Netherlands

      Cuijpers CEJ; Zeilmaker MJ; van der Molen GW; Slob W; Lebret E; CCM; LBO; Vrije Universiteit van Amsterdam; afdeling Theoretische Biologie. (Rijksinstituut voor Volksgezondheid en Milieu RIVM, 1997-11-30)
      This report describes the evaluation of the time trend by means of PBPK modelling, and the associated health effects of pre- and postnatal exposure of infants to dioxins, furans and PCBs. Using PBPK modelling there was an expected decrease of ca. 20% in dioxin levels in human milk shown for 1998 compared to 1993. Evaluation of the epidemiological literature resulted in critical remarks on the exposure characterisation and the data analyses of the studies. Lack of convincing exposure-response relationships meant that no quantitative assessment of the associated health risk in infants could be performed. Pooled and/or re-analysis of the existing data could shed some light on the apparant inconsistencies reported so far.<br>