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dc.contributor.authorDerks HJGM
dc.contributor.authorBerende PLM
dc.contributor.authorOlling M
dc.contributor.authorLiem AKD
dc.contributor.authorEverts H
dc.contributor.authorJong APJM de
dc.date.accessioned2012-12-12T12:50:16Z
dc.date.available2012-12-12T12:50:16Z
dc.date.issued1991-03-31
dc.identifier328904002
dc.identifier.urihttp://hdl.handle.net/10029/255955
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractFollowing a previously published report on an investigation into the pharmacokinetics of 13C-labelled polychlorinated dibenzo-p-dioxins and dibenzofurans administered orally as a bolus to lactating cows, the present report describes the elimination kinetics of unlabelled dioxins ingested by the same cows while being kept in contaminated pastures in the Lickebaert-area. A control animal not knwon to be exposed to dioxins in excess of background levels showed dioxin concentrations in milk and subcutaneous fat as expected except for two congeners indicating a possible accidental exposure to pentachlorophenol. From the dioxin concentrations in milk and subcutaneous fat of the Lickebaert cows half lifes could be calculated for nine congeners. In general the elimination half lifes as judged from milk concentrations appeared to be longer (45-110 d) than found previously for labelled dioxins. This phenomenon was most striking for the higher substituted congeners. The values found for the TEQ-dominating congeners did not differ essentially from those found before. In subcutaneous fat half lifes appeared to be shorter (25-40 d) than those derived from milk data. The discrepancies between the milk and subcutaneous fat data observed here and between the present results and those reported previously may be due to physiologic and kinetic processes occurring in the lactating cow.
dc.description.sponsorshipVHI LNV/DLO
dc.format.extent29 p
dc.language.isonl
dc.relation.ispartofRIVM Rapport 328904002
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/328904002.html
dc.subject07nl
dc.subject91-2nl
dc.titleDe toxicokinetiek van PCDD's en PCDF's in de lacterende koe (II)nl
dc.title.alternativeThe toxicokinetics of PCDDs and PCDFs in the lactating cow (II)en
dc.typeOnderzoeksrapport
dc.date.updated2012-12-12T12:50:17Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractFollowing a previously published report on an investigation into the pharmacokinetics of 13C-labelled polychlorinated dibenzo-p-dioxins and dibenzofurans administered orally as a bolus to lactating cows, the present report describes the elimination kinetics of unlabelled dioxins ingested by the same cows while being kept in contaminated pastures in the Lickebaert-area. A control animal not knwon to be exposed to dioxins in excess of background levels showed dioxin concentrations in milk and subcutaneous fat as expected except for two congeners indicating a possible accidental exposure to pentachlorophenol. From the dioxin concentrations in milk and subcutaneous fat of the Lickebaert cows half lifes could be calculated for nine congeners. In general the elimination half lifes as judged from milk concentrations appeared to be longer (45-110 d) than found previously for labelled dioxins. This phenomenon was most striking for the higher substituted congeners. The values found for the TEQ-dominating congeners did not differ essentially from those found before. In subcutaneous fat half lifes appeared to be shorter (25-40 d) than those derived from milk data. The discrepancies between the milk and subcutaneous fat data observed here and between the present results and those reported previously may be due to physiologic and kinetic processes occurring in the lactating cow.


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