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    A double-blind, randomized, placebo-controlled, cross-over study on the pharmacokinetics and effects of cannabis

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    Authors
    Mensinga TjT
    de Vries I
    Kruidenier M
    Hunault CC
    van den Hengel-Koot IS
    Fijen JW
    Leenders MEC
    Meulenbelt J
    Mensinga TjT
    Meulenbelt J
    Series/Report no.
    RIVM rapport 267002002
    Type
    Report
    Language
    en
    
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    Title
    A double-blind, randomized, placebo-controlled, cross-over study on the pharmacokinetics and effects of cannabis
    Translated Title
    Dubbel-blind, gerandomiseerd, placebo-gecontroleerd, 4-weg gekruist onderzoek naar de farmacokinetiek en effecten van cannabis
    Publiekssamenvatting
    Systematische metingen van de concentratie van de psychoactieve stof THC in 'nederwiet' cannabis afkomstig van coffeeshops in Nederland, hebben laten zien dat de gemiddelde THC concentraties geleidelijk aan zijn gestegen van circa 8,6% in december 1999-januari 2000 tot 17,7% in december 2004-januari 2005. Het roken van cannabis met hogere THC-gehaltes (externe blootstelling: 9,75 tot 23,12% THC) gaat gepaard met een dosis-gerelateerde toename van de serumconcentratie van THC (de inwendige blootstelling).
    Het roken van cannabis met hogere THC-gehaltes vervolgens gaat tevens gepaard met een dosis-gerelateerde toename van lichamelijke effecten (zoals hartslagverhoging, bloeddruk-verlaging) en psychomotorische effecten (zoals trager reageren, concentratievermindering, het maken van meer fouten bij het testen en het slechter functioneren van de spiercoordinatie en meer slaperigheid). Bovengenoemde resultaten komen voort uit een klinische studie met 24 cannabisgebruikers.

    Systematic measurements of the concentration of the psycho-active substance delta-9- tetrahydrocannabinol (THC) in 'netherweed' cannabis obtained from coffeeshops in the Netherlands have revealed that the mean THC concentrations have steadily increased from circa 8.6% in December 1999-January 2000 to 17.7% in December 2004-January 2005. Smoking cannabis with higher THC contents (external exposure: 9.75 to 23.12% THC) was associated with a dose-related increase of the serum concentrations of THC (internal exposure).
    Smoking cannabis with higher THC contents was also associated with a dose-related increase of physical effects (such as increase of heart rate, and decrease of blood pressure) and psychomotor effects (such as reacting more slowly, being less concentrated, making more mistakes during testing, having decreased functioning of motor control, and having more drowsiness). Results as mentioned above were derived from a clinical study with 24 cannabis users.
    Description
    Dutch translation: RIVM report 267002001<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    VWS
    URI
    http://hdl.handle.net/10029/256056
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