Presentation and analysis of a general algorithm for risk-assessment on secondary poisoning
dc.contributor.author | Romijn CAFM | |
dc.contributor.author | Luttik R | |
dc.contributor.author | van de Meent D | |
dc.contributor.author | Slooff W | |
dc.contributor.author | Canton JH | |
dc.date.accessioned | 2017-02-20T06:46:30 | |
dc.date.issued | 1991-06-30 | |
dc.identifier | 679102002 | |
dc.description.abstract | The study in this report was carried out in the frame of the project "Evaluation system for new chemical substances". The aim of the study was to present a general algorithm for risk-assessment on secondary poisoning of birds and mammals. Risk-assessment on secondary poisoning can be an asset to risk-assessment on direct poisoning in setting quality standards for the environment. The water - fish - fish-eating bird or mammal pathway was analyzed as an example of a secondary poisoning pathway. Parameters used for the algorithm are the bioconcentration factor for fish (BCF) and the no-observed effect concentration for the group of fish-eating birds and mammals (NOEC fish- eater). For the derivation of reliable BCF's preference is given to the use of experimentally derived BCF's over QSAR estimates. NOEC's for fish-eaters are dervied by extrapolating toxicity data on single species. Because, data on fish-eating species are seldom available, toxocity data on all bird and mammalian species were used. The proposed algorithm (MTR = NOEC fish-eater / BCF) was used to calculate maximum tolerable risk levels (MTR's) for the compounds: lindane, dieldrin, cadmium, mercury, PCB153 and PCB118. It was concluded that for mercury and dieldrin secondary poisoning of fish-eating birds and mammals can occur at levels in surface water below the MTR calculated by risk-assessment for aquatic organisms. Secondary poisoning of fish- eating birds and mammals is not likely to occur for cadmium at levels in water below the MTR calculated for aquatic organisms.<br> | |
dc.description.sponsorship | DGM/SR | |
dc.format | application/pdf | |
dc.format.extent | 55 p | |
dc.format.extent | 2097 kb | |
dc.language.iso | en | |
dc.publisher | Rijksinstituut voor Volksgezondheid en Milieu RIVM | |
dc.relation.ispartof | RIVM Rapport 679102002 | |
dc.relation.url | http://www.rivm.nl/bibliotheek/rapporten/679102002.html | |
dc.relation.url | http://www.rivm.nl/bibliotheek/rapporten/679102002.pdf | |
dc.subject | 07 | nl |
dc.subject | 91-3 | nl |
dc.subject | risico-schatting | nl |
dc.subject | doorvergiftiging | nl |
dc.subject | vogels | nl |
dc.subject | zoogdieren; risk-assessment | nl |
dc.subject | secondary poisoning | nl |
dc.subject | birds | nl |
dc.subject | mammels | nl |
dc.title | Presentation and analysis of a general algorithm for risk-assessment on secondary poisoning | en |
dc.title.alternative | Presentatie en analyse van een rekenmodel voor risicoschatting bij doorvergiftiging | nl |
dc.type | Report | |
dc.date.updated | 2017-02-20T05:46:30Z | |
html.description.abstract | The study in this report was carried out in the frame of the project "Evaluation system for new chemical substances". The aim of the study was to present a general algorithm for risk-assessment on secondary poisoning of birds and mammals. Risk-assessment on secondary poisoning can be an asset to risk-assessment on direct poisoning in setting quality standards for the environment. The water - fish - fish-eating bird or mammal pathway was analyzed as an example of a secondary poisoning pathway. Parameters used for the algorithm are the bioconcentration factor for fish (BCF) and the no-observed effect concentration for the group of fish-eating birds and mammals (NOEC fish- eater). For the derivation of reliable BCF's preference is given to the use of experimentally derived BCF's over QSAR estimates. NOEC's for fish-eaters are dervied by extrapolating toxicity data on single species. Because, data on fish-eating species are seldom available, toxocity data on all bird and mammalian species were used. The proposed algorithm (MTR = NOEC fish-eater / BCF) was used to calculate maximum tolerable risk levels (MTR's) for the compounds: lindane, dieldrin, cadmium, mercury, PCB153 and PCB118. It was concluded that for mercury and dieldrin secondary poisoning of fish-eating birds and mammals can occur at levels in surface water below the MTR calculated by risk-assessment for aquatic organisms. Secondary poisoning of fish- eating birds and mammals is not likely to occur for cadmium at levels in water below the MTR calculated for aquatic organisms.<br> |