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dc.contributor.authorRomijn CAFM
dc.contributor.authorLuttik R
dc.contributor.authorvan de Meent D
dc.contributor.authorSlooff W
dc.contributor.authorCanton JH
dc.date.accessioned2017-02-20T06:46:30
dc.date.issued1991-06-30
dc.identifier679102002
dc.description.abstractThe study in this report was carried out in the frame of the project "Evaluation system for new chemical substances". The aim of the study was to present a general algorithm for risk-assessment on secondary poisoning of birds and mammals. Risk-assessment on secondary poisoning can be an asset to risk-assessment on direct poisoning in setting quality standards for the environment. The water - fish - fish-eating bird or mammal pathway was analyzed as an example of a secondary poisoning pathway. Parameters used for the algorithm are the bioconcentration factor for fish (BCF) and the no-observed effect concentration for the group of fish-eating birds and mammals (NOEC fish- eater). For the derivation of reliable BCF's preference is given to the use of experimentally derived BCF's over QSAR estimates. NOEC's for fish-eaters are dervied by extrapolating toxicity data on single species. Because, data on fish-eating species are seldom available, toxocity data on all bird and mammalian species were used. The proposed algorithm (MTR = NOEC fish-eater / BCF) was used to calculate maximum tolerable risk levels (MTR's) for the compounds: lindane, dieldrin, cadmium, mercury, PCB153 and PCB118. It was concluded that for mercury and dieldrin secondary poisoning of fish-eating birds and mammals can occur at levels in surface water below the MTR calculated by risk-assessment for aquatic organisms. Secondary poisoning of fish- eating birds and mammals is not likely to occur for cadmium at levels in water below the MTR calculated for aquatic organisms.<br>
dc.description.sponsorshipDGM/SR
dc.formatapplication/pdf
dc.format.extent55 p
dc.format.extent2097 kb
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 679102002
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/679102002.html
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/679102002.pdf
dc.subject07nl
dc.subject91-3nl
dc.subjectrisico-schattingnl
dc.subjectdoorvergiftigingnl
dc.subjectvogelsnl
dc.subjectzoogdieren; risk-assessmentnl
dc.subjectsecondary poisoningnl
dc.subjectbirdsnl
dc.subjectmammelsnl
dc.titlePresentation and analysis of a general algorithm for risk-assessment on secondary poisoningen
dc.title.alternativePresentatie en analyse van een rekenmodel voor risicoschatting bij doorvergiftigingnl
dc.typeReport
dc.date.updated2017-02-20T05:46:30Z
html.description.abstractThe study in this report was carried out in the frame of the project &quot;Evaluation system for new chemical substances&quot;. The aim of the study was to present a general algorithm for risk-assessment on secondary poisoning of birds and mammals. Risk-assessment on secondary poisoning can be an asset to risk-assessment on direct poisoning in setting quality standards for the environment. The water - fish - fish-eating bird or mammal pathway was analyzed as an example of a secondary poisoning pathway. Parameters used for the algorithm are the bioconcentration factor for fish (BCF) and the no-observed effect concentration for the group of fish-eating birds and mammals (NOEC fish- eater). For the derivation of reliable BCF&apos;s preference is given to the use of experimentally derived BCF&apos;s over QSAR estimates. NOEC&apos;s for fish-eaters are dervied by extrapolating toxicity data on single species. Because, data on fish-eating species are seldom available, toxocity data on all bird and mammalian species were used. The proposed algorithm (MTR = NOEC fish-eater / BCF) was used to calculate maximum tolerable risk levels (MTR&apos;s) for the compounds: lindane, dieldrin, cadmium, mercury, PCB153 and PCB118. It was concluded that for mercury and dieldrin secondary poisoning of fish-eating birds and mammals can occur at levels in surface water below the MTR calculated by risk-assessment for aquatic organisms. Secondary poisoning of fish- eating birds and mammals is not likely to occur for cadmium at levels in water below the MTR calculated for aquatic organisms.&lt;br&gt;


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