Toxicological investigation of benzylbutylphthalate in rats
dc.contributor.author | van den Ham WA | |
dc.contributor.author | Jansen EHJM | |
dc.contributor.author | de Fluiter P | |
dc.contributor.author | van Leeuwen FXR | |
dc.date.accessioned | 2014-01-17T13:46:52 | |
dc.date.issued | 1992-12-31 | |
dc.identifier | 618902010 | |
dc.description.abstract | In a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg benzylbutylphthalate (BBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates. No effect has been observed on the liver weight. The body weight showed a significant decrease as the highest dose level. PCO and CAT showed no effect up to 600 mg BBP/kg diet. LAH was more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet, corresponding with 19.1 mg BBP/kg b.w./day. ECH appeared to be the most sensitive parameter with an effect in all dose levels used. Therefore, no overall no-observed effect level can be defined in this experiment.<br> | |
dc.description.sponsorship | HIGB | |
dc.format.extent | 33 p | |
dc.language.iso | en | |
dc.publisher | Rijksinstituut voor Volksgezondheid en Milieu RIVM | |
dc.relation.ispartof | RIVM Rapport 618902010 | |
dc.relation.url | http://www.rivm.nl/bibliotheek/rapporten/618902010.html | |
dc.subject | 07 | nl |
dc.subject | ftalaten | nl |
dc.subject | benzylbutylftalaat | nl |
dc.subject | toxiciteitstest | nl |
dc.subject | dierproeven | nl |
dc.subject | enzymen | nl |
dc.subject | phthalates | en |
dc.subject | benzylbutylphthalate | en |
dc.subject | toxicity testing | en |
dc.subject | nel | en |
dc.subject | animal models | en |
dc.subject | enzymes | en |
dc.title | Toxicological investigation of benzylbutylphthalate in rats | en |
dc.title.alternative | [Toxicologisch onderzoek naar benzylbutylftalaat in ratten.] | nl |
dc.type | Report | |
dc.date.updated | 2014-01-17T12:49:23Z | |
html.description.abstract | In a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg benzylbutylphthalate (BBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates. No effect has been observed on the liver weight. The body weight showed a significant decrease as the highest dose level. PCO and CAT showed no effect up to 600 mg BBP/kg diet. LAH was more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet, corresponding with 19.1 mg BBP/kg b.w./day. ECH appeared to be the most sensitive parameter with an effect in all dose levels used. Therefore, no overall no-observed effect level can be defined in this experiment.<br> |