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dc.contributor.authorde Neeling AJ
dc.contributor.authorOverbeek BP
dc.contributor.authorTimmerman CP
dc.contributor.authorde Jong J
dc.contributor.authorDessens-Kroon M
dc.contributor.authorvan Klingeren B
dc.date.accessioned2017-02-20T07:25:13
dc.date.issued1992-07-31
dc.identifier359001003
dc.description.abstractThe susceptibility to antibiotics of three respiratory pathogens, Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, was determined. The isolates were obtainied in three regional laboratories in the Netherlands and tested using the microdilution method. After incubation the turbidity was measured in a fotometer and the results were analysed at the RIVM by a computer program. Not all isolates grew well in the broth medium chosen and the resistance of a small number of strains retested on agar, was not confirmed. So the broth medium still needs improvement and the method must be compared with the established agar-dilution technique. Nevertheless the results of the investigation confirmed those of earlier research. Most isolates were still sensitive to commonly used antibiotics. The known insensitivity of Haemophilus influenzae to erythromycin and the marginal susceptibility of Streptococcus pneumoniae to quinolones was confirmed. Resistance of Haemophilus influenzae to amoxycillin was found in 10% of the isolates, mostly due to beta-lactamase production. Reduced susceptibility of Streptococcus pneumoniae to penicillin was found in approximately 2% of the isolates.<br>
dc.description.sponsorshipRIVM
dc.description.sponsorshipEli Lilly BV Nieuwegein
dc.description.sponsorshipGlaxo BV Nieuwegein
dc.description.sponsorshipMerck Sharp &amp; Dohme BV Haarlem
dc.description.sponsorshipSmith Kline Beecham BV Rijswijk
dc.format.extent23 p
dc.language.isonl
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 359001003
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/359001003.html
dc.subject01nl
dc.subjectluchtweginfectiesnl
dc.subjectpathogenennl
dc.subjectstreptococcus pneumoniaenl
dc.subjecthaemophilus influenzaenl
dc.subjectmoraxella catarrhalisnl
dc.subjectresistentienl
dc.subjectantibioticanl
dc.subjectluchtweg pathogenennl
dc.subjectmicrodilutienl
dc.subjectrespiratory tract infectionsen
dc.subjectpathogensen
dc.subjectstreptococcus pneumoniaeen
dc.subjecthaemophilus influenzaeen
dc.subjectmoraxella catarrhalisen
dc.subjectmicrobial drug resistanceen
dc.subjectantibioticsen
dc.titleOnderzoek naar de gevoeligheid van streptococcus pneumoniae, haemophilus influenzae en Moraxella catarrhalis voor antibioticanl
dc.title.alternativeResearch of the susceptibility to antibiotics of Streptococcus pneumoniae, Haemophilus influenzae Moraxella catarrhalisen
dc.typeOnderzoeksrapport
dc.date.updated2017-02-20T06:25:13Z
html.description.abstractThe susceptibility to antibiotics of three respiratory pathogens, Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, was determined. The isolates were obtainied in three regional laboratories in the Netherlands and tested using the microdilution method. After incubation the turbidity was measured in a fotometer and the results were analysed at the RIVM by a computer program. Not all isolates grew well in the broth medium chosen and the resistance of a small number of strains retested on agar, was not confirmed. So the broth medium still needs improvement and the method must be compared with the established agar-dilution technique. Nevertheless the results of the investigation confirmed those of earlier research. Most isolates were still sensitive to commonly used antibiotics. The known insensitivity of Haemophilus influenzae to erythromycin and the marginal susceptibility of Streptococcus pneumoniae to quinolones was confirmed. Resistance of Haemophilus influenzae to amoxycillin was found in 10% of the isolates, mostly due to beta-lactamase production. Reduced susceptibility of Streptococcus pneumoniae to penicillin was found in approximately 2% of the isolates.&lt;br&gt;


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