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    Toxiciteit van beta-HCH. Relatie biochemie en pathologie van de lever in een 6-weekse voederproef

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    Authors
    van Giersbergen PLM
    van Velsen FL
    van Leeuwen FXR
    Danse LHJC
    Type
    Report
    Language
    nl
    
    Metadata
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    Title
    Toxiciteit van beta-HCH. Relatie biochemie en pathologie van de lever in een 6-weekse voederproef
    Translated Title
    Toxicity of beta-HCH. Relation of biochemical and histopathological effects on liver in a 6-weeks feeding study
    Publiekssamenvatting
    De doseringen in de 6-weekse voederproef waren 0, 2, 10, 50 of 250 mg/kg voer. Het biochemisch onderzoek omvatte bepalingen van de activiteit van microsomale leverenzymen, bepalingen van gehalte eiwit, RNA en DNA in lever. Het histopathologisch onderzoek was gericht op de vaststelling van met enzyminductie gerelateerde lesies in de lever. De conclusie van beide onderzoekingen was dat alleen in de 250 mg/kg voer-groep enzyminductie optrad. De eveneens waargenomen toename van het levergewicht in deze groep kan verklaard worden door hyperplasie en hypertrofie. Andere processen lijken echter ook een rol te spelen.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    HIL
    URI
    http://hdl.handle.net/10029/256469
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