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dc.contributor.authorEigeman L
dc.contributor.authorJansen van 't Land C
dc.contributor.authorvan der Laan JW
dc.date.accessioned2017-02-20T07:02:24
dc.date.issued1990-05-31
dc.identifier318510005
dc.description.abstractWithdrawal of benzodiazepines after long term treatment may induce hallucinatory symptoms and can evoke delusional depressions. Mesolimbic dopaminergic activity may be specifically involved in the development of benzodiazepine withdrawal. Acute administration of benzodiazepines did hardly affect the dopamine turnover in the nucleus accumbens. Therefore, the dopamine turnover has to be activated to study the effects of benzodiazepines. We have used haloperidol to activate the dopamine system. Activation of the dopamine turnover after administration of haloperidol can be suppressed by benzodiazepines effectively. The results point to a selective effect on benzodiazepines in the nuclus accumbens.<br>
dc.description.sponsorshipHIG
dc.description.sponsorshipCBG
dc.format.extent43 p
dc.language.isonl
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 318510005
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/318510005.html
dc.subject08nl
dc.subjectdopaminenl
dc.subjecthaloperidolnl
dc.subjectbenzodiazepinennl
dc.subjectratnl
dc.titleAcute effecten van benzodiazepinen op de turnover van dopamine in een geactiveerd systeem bij de ratnl
dc.title.alternativeAcute effects of benzodiazepines on the turnover of dopamine in an activated system in the raten
dc.typeReport
dc.date.updated2017-02-20T06:02:24Z
html.description.abstractWithdrawal of benzodiazepines after long term treatment may induce hallucinatory symptoms and can evoke delusional depressions. Mesolimbic dopaminergic activity may be specifically involved in the development of benzodiazepine withdrawal. Acute administration of benzodiazepines did hardly affect the dopamine turnover in the nucleus accumbens. Therefore, the dopamine turnover has to be activated to study the effects of benzodiazepines. We have used haloperidol to activate the dopamine system. Activation of the dopamine turnover after administration of haloperidol can be suppressed by benzodiazepines effectively. The results point to a selective effect on benzodiazepines in the nuclus accumbens.&lt;br&gt;


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