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dc.contributor.authorSpeijers GJA
dc.contributor.authorJanssen GB
dc.contributor.authorWallbrink-de Dreu Y
dc.contributor.authorvan Leeuwen FXR
dc.contributor.authorvan Loenen HA
dc.contributor.authorKrajnc-Franken MAM
dc.contributor.authorVaessen HAMG
dc.contributor.authorWester PW
dc.date.accessioned2012-12-12T14:16:45Z
dc.date.available2012-12-12T14:16:45Z
dc.date.issued1993-05-31
dc.identifier618311002
dc.identifier.urihttp://hdl.handle.net/10029/256628
dc.description.abstractA subchronic toxicity experiment with propyl gallate in SPF-derived Wistar RIVM:TOX rats was performed. Groups of 10 female and 10 male rats were fed a semisynthetic diet containing 0, 490, 1910 and 7455 mg propyl gallate /kg feed. Body weight gain was recorded weekly and food-intake twice weekly. Other parameters comprised haematology, biochemical determinations in urine, serum and liver and complete histopathological examinations. Adverse effects of propyl gallate observed in the high dose group were effects on the haemopoeitic system reflected in the haematological parameters and the morphological changes in the spleen. The other effects observed comprised decreased incidence of the nephrocalcinosis in female rats, the increased activity of EROD in the high dose group and increased activity of the conjugating enzymes; glucorynyl-transferase and glutathion-s-transferase, in the mid and high dose group of propyl gallate. The effects on the nephrocalcinosis and on the conjugating enzymes may be considered as not adverse. The no observed adverse effect level (NOAEL) is 1910 mg propyl gallate /kg feed corresponding with 135 mg propyl gallate /kg body weight.<br>
dc.description.sponsorshipHIGB
dc.format.extent20 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 618311002
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618311002.html
dc.subject07nl
dc.subjectgallatennl
dc.subjectpropylgallaatnl
dc.subjecttoxiciteitstestennl
dc.subjectdiermodelnl
dc.subjecthaematopietisch systeemnl
dc.subjectgallatesen
dc.subjectpropyl-gallateen
dc.subjecttoxicity testingen
dc.subjectanimal modelsen
dc.subjecthematopoietic systemen
dc.titleSubchronic toxicity of propyl-gallateen
dc.title.alternative[Subchronische toxiciteit van propylgallaat.]nl
dc.typeOnderzoeksrapport
dc.date.updated2012-12-12T14:16:45Z
html.description.abstractA subchronic toxicity experiment with propyl gallate in SPF-derived Wistar RIVM:TOX rats was performed. Groups of 10 female and 10 male rats were fed a semisynthetic diet containing 0, 490, 1910 and 7455 mg propyl gallate /kg feed. Body weight gain was recorded weekly and food-intake twice weekly. Other parameters comprised haematology, biochemical determinations in urine, serum and liver and complete histopathological examinations. Adverse effects of propyl gallate observed in the high dose group were effects on the haemopoeitic system reflected in the haematological parameters and the morphological changes in the spleen. The other effects observed comprised decreased incidence of the nephrocalcinosis in female rats, the increased activity of EROD in the high dose group and increased activity of the conjugating enzymes; glucorynyl-transferase and glutathion-s-transferase, in the mid and high dose group of propyl gallate. The effects on the nephrocalcinosis and on the conjugating enzymes may be considered as not adverse. The no observed adverse effect level (NOAEL) is 1910 mg propyl gallate /kg feed corresponding with 135 mg propyl gallate /kg body weight.&lt;br&gt;


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