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    Verdeling van platina over weefsels en lichaamsvloeistoffen bij de rat na intraperitoneale toediening van cis-platina verpakt in liposomen en IgG-liposomen

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    Authors
    Tjebbes CM
    de Groot G
    Wubs KL
    de Jong WH
    Nassander UK
    Type
    Report
    Language
    nl
    
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    Title
    Verdeling van platina over weefsels en lichaamsvloeistoffen bij de rat na intraperitoneale toediening van cis-platina verpakt in liposomen en IgG-liposomen
    Translated Title
    Distribution of platinum in tissues and body fluids of rats after intraperitoneal administration of cis-platinum encapsulated in liposomes and IgG-liposomes
    Publiekssamenvatting
    Er wordt een onderzoek beschreven naar verbetering van de therapeutische index van het cytostaticum cis-diamminedichloroplatinum (II) (cDDP) door cDDP te verpakken in liposomen. In twee in-vivo-experimenten is de verdeling van platina over weefsels en lichaamsvloeistoffen bij de rat bestudeerd na intraperitoneale toediening van cDDP verpakt in liposomen en IgG-liposomen. Toediening op deze wijze leidt tot een verlengde verblijftijd van het cytostaticum in de buikholte t.o.v. toediening van vrij cDDP. Opname van cDDP in lever, longen en milt wordt vergroot. Een derde in-vivo-experiment toont aan dat liposomen via de lymfen uit de buikholte verdwijnen.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    GMI
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