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    Dierexperimentele behandeling van paraquat- toxiciteit met desferrioxamine, gewassen erythrocyten of erythrocyten-cytosol

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    Authors
    Boonen
    H.C.M.*
    Hillen
    F.C.
    Jong
    Y.de
    Timmerman
    A.
    Dormans
    J.A.M.A.
    Asbeck
    B.S.van*
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    Type
    Report
    Language
    nl
    
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    Title
    Dierexperimentele behandeling van paraquat- toxiciteit met desferrioxamine, gewassen erythrocyten of erythrocyten-cytosol
    Translated Title
    Treatment of paraquat toxicity with desferrioxamine washed erythrocytes or erythrocyte-cytosol in animal experiments
    Publiekssamenvatting
    Een paraquat intoxicatie bij de rat kon met de ijzerchelator desferrioxiamine via een chronisch infuus worden tegengegaan: het overlevingspercentage bleek tot 66,6% te stijgen na een desferrioxamine infuus van 100 mg/kg/24uur. Gewassen erythrocyten en cytosol hadden na intratracheale toediening geen invloed op de paraquat toxiciteit. De zuurstof toxiciteit bij de rat (100% zuurstof) kon worden tegengegaan met gewassen erythrocyten, niet met cytosol.
    Abstract not available
    Sponsors
    RIVM
    URI
    http://hdl.handle.net/10029/256733
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