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    Onderzoek naar de effecten van verschillende doseringen glycyrrhizine bij gezonde vrouwelijke vrijwilligers

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    Authors
    Bijlsma JA
    van Vloten P
    van Gelderen CEM
    Mensinga TjT
    Mout HA
    Elvers LH
    van Leeuwen FXR
    Stolker AAM
    van Ginkel LA
    Looman CWN
    van der Maas PJ
    Koomans HA
    Savelkoul TJF
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    Type
    Report
    Language
    nl
    
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    Title
    Onderzoek naar de effecten van verschillende doseringen glycyrrhizine bij gezonde vrouwelijke vrijwilligers
    Translated Title
    An assessment of the effects of various dosages of glycyrrhizin in healthy female volunteers
    Publiekssamenvatting
    Teneinde een "no effect level" van glycyrrhizine vast te stellen, werd een dubbelblind, gerandomiseerd, gecontroleerd onderzoek uitgevoerd bij 39 gezonde vrouwelijke vrijwilligers. Gedurende 8 weken werd glycyrrhizine in een dosis van 0, 1, 2 of 4 mg per kg lichaamsgewicht ingenomen. De doseringen en de keus voor vrouwelijke deelnemers waren gebaseerd op een voorafgaand pilot onderzoek. De volgende parameters werden bestudeerd: gewicht, bloeddruk, electrolyten concentratie in plasma, 24-uurs excretie van electrolyten in urine, plasma renine activiteit, plasma aldosteron concentratie, atriaal natriuretisch peptide concentratie en de concentratie van glycyrrhetinezuur in plasma. De deelnemers hielden een klachtenlogboek en eetdagboekjes bij. Alleen in de hoogste doseringsgroep van 4 mg glycyrrhizine per kg lichaamsgewicht werden effecten waargenomen. Deze betroffen volume expansie enerzijds en veranderingen in plasma electrolyten anderzijds. De volume expansie tijdens glycyrrhizine-inname kwam tot uiting in suppressie van het renine-angiotensine-aldosteron systeem en toename van gewicht. Tevens daalde de atriaal natriuretisch peptide-concentratie na het staken van de glycyrrhizine-inname. De electrolytveranderingen betroffen daling van plasma kalium en stijging van plasma bicarbonaat-concentratie tijdens de glycyrrhizine-inname. Op grond van deze gegevens kan een "no effect level" van 2 mg glycyrrhizine per kg lichaamsgewicht per dag worden afgeleid.<br>
    In order to define a "no effect level" for glycyrrhizin, a double-blind, randomized controlled study was conducted in 39 healthy female volunteers. The volunteers took a daily dosage of either 0, 1, 2 or 4 mg glycyrrhizin per kg bodyweight for a period of 8 weeks. The dosages and the preference for female volunteers were based on a previous pilot study. The following parameters were studied: bodyweight, blood pressure, plasma electrolytes, 24 hour urinary excretion of electrolytes, plasma renin activity, plasma aldosterone concentration, plasma atrial natriuretic peptide concentration and plasma glycyrrhetic acid concentration. The participants kept a journal of complaints and diet. Effects were observed in the highest dosage group only (4 mg glycyrrhizin per kg bodyweight). These concerned volume expansion on the one hand and changes in plasma electrolyte concentration on the other. Volume expansion during intake of glycyrrhizin was indicated by suppression of the renin-angiotensin-aldosterone system and by weight gain. The changes in electrolyte concentration were a decline in plasma potassium concentration and a rise in plasma bicarbonate concentration during glycyrrhizin intake. Besides, the atrial natriuretic peptide concentration decreased after discontinuation of glycyrrhizin intake. The changes in electrolyte concentration concerned a decline in plasma potassium concentration and a rise in plasma bicarbonate concentration during glycyrrhizin intake. Based on this study, the "no effect level" for glycyrrhizin is concluded to be 2 mg per kg bodyweight.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    HIGB/VVP
    URI
    http://hdl.handle.net/10029/256738
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