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    Onderzoek naar de inductie van chromosoomafwijkingen en "sister- chromatid exchanges" door methylmethacrylaat met Chinese hamster cellen in vitro

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    Authors
    Knaap
    A.G.A.C.
    Bergkamp
    W.G.M.
    Groot
    M.G.
    Type
    Report
    Language
    nl
    
    Metadata
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    Title
    Onderzoek naar de inductie van chromosoomafwijkingen en "sister- chromatid exchanges" door methylmethacrylaat met Chinese hamster cellen in vitro
    Translated Title
    Induction of chromosome abberations and "sister-chromatid exchanges" by methylmethacrylate with Chinese hamster cells in vitro
    Publiekssamenvatting
    Methylmethacrylaat of methacrylzure-methyl-ester bleek een clastogene werking te hebben in een test op chromosoomafwijkingen met Chinese hamster cellen in vitro, zowel in afwezigheid van een systeem voor metabolische activering (S9), bij concentraties vanaf 3 ul/ml 28,2 mmol/l), als in aanwezigheid van metabolische activering (S9) bij concentraties vanaf 2 ul/ml (18,8 mmol/l). Tevens induceerde methylmethacrylaat in deze cellen een significante toename in het aantal zuster-chromatide uitwisselingen (SCE's) per cel, zowel in afwezigheid van metabolische activering bij concentraties vanaf 2 ul/ml, als in aanwezigheid van metabolische activering bij concentraties vanaf 0,5 ul/ml (4,7 mmol/l).
    Abstract not available
    Sponsors
    HIL
    URI
    http://hdl.handle.net/10029/256781
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