N-Nitrosodiethanolamine (NDELA) in cosmetica methode ontwikkeling en monster analyse
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Type
OnderzoeksrapportLanguage
nl
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N-Nitrosodiethanolamine (NDELA) in cosmetica methode ontwikkeling en monster analyseTranslated Title
N-Nitrosodiethanolamine (NDELA) in cosmetics method development and sample analysisPubliekssamenvatting
In 1995 is op verzoek van de Inspectie Gezondheids Bescherming de N-nitrosamine problematiek in cosmetische producten in kaart gebracht. Voor het bepalen van NDELA in cosmetica is de GC-TEA methode ontwikkeld en gevalideerd. De terugwinning voor NDELA is gemiddeld 99% (N=4) en de bepaalbaarheidsgrens is 5 mug NDELA / kg cosmetica. De GC-TEA methode is gebruikt om in 48 cosmetische producten, waaronder shampoos, cremes, melk , conditioners en schuimen het NDELA gehalte te bepalen. Alle bepalingen werden in tweevoud uitgevoerd en voor elke 10 cosmetica monsters is een terugwinnings- en blanco-experiment uitgevoerd. De resultaten van deze kwaliteitsexperimenten voldeden aan de kwaliteitskenmerken van de ontwikkelde methode.Van de 48 onderzochte monsters cosmetica bevatten vier monsters meetbare hoeveelheden NDELA.In response to the 1995 review of the N-nitrosamine problem in cosmetics at the request of the Inspectorate of Health Protection (IGB), a GC-TEA method for determining NDELA in cosmetics has been developed and validated. In a sample diluted with water, adsorbed onto a kieselguhr column and eluted with n-butanol, the average recovery for NDELA is 99% (N=4) and the limit of quantification 5 mug/kg. The GC-TEA method described was used to determine the NDELA content of 48 cosmetics including gels, shampoos, cremes, milks, conditioners and foams. All determinations were done in duplicate and for every 10 cosmetics a recovery experiment and a blank determination were performed. The results of these quality assurance experiments were within the performance characteristics of the method developed. Amounts of NDELA above the limit of quantification of 5 mug/kg were measured in 4 out of the 48 cosmetics.
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