Show simple item record

dc.contributor.authorJansen EHJM
dc.contributor.authorvan den Ham WA
dc.contributor.authorde Fluiter P
dc.contributor.authorvan Leeuwen FXR
dc.date.accessioned2017-02-20T06:52:22
dc.date.issued1992-12-31
dc.identifier618902008
dc.description.abstractIn a study in which male rats have been exposed to 0,20, 60, 200, 600 and 2000 mg di(isononyl)phthalate (DINP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates which are related with peroxisome proliferation. No effects have been observed on both liver and body weight. PCO, CAT and LAH, showed no effect at 200 mg DINP/kg diet, corresponding with 18.2 mg/kg b.w./day. ECH appeared to be the most sensitive parameter with a dose-without-effect of 60 mg DINP/kg diet, corresponding to 5.7 mg DINP/kg b.w./day. This value of 60 mg/kg diet has been defined as overall no-observed-effect-level for DINP in this experiment.<br>
dc.description.sponsorshipHIGB
dc.format.extent31 p
dc.language.isoen
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM
dc.relation.ispartofRIVM Rapport 618902008
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902008.html
dc.subject07nl
dc.subjectftalatennl
dc.subjecttoxiciteitstestennl
dc.subjectdiermodelnl
dc.subjectenzymennl
dc.subjectphthalatesen
dc.subjecttoxicity testingen
dc.subjectanimal modelsen
dc.subjectenzymesen
dc.subjectdinpen
dc.titleToxicological investigation of di(isononyl]phthalate in ratsen
dc.title.alternative[Toxicologisch onderzoek naar di(isononyl)ftalaat in ratten.]nl
dc.typeReport
dc.date.updated2017-02-20T05:52:23Z
html.description.abstractIn a study in which male rats have been exposed to 0,20, 60, 200, 600 and 2000 mg di(isononyl)phthalate (DINP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates which are related with peroxisome proliferation. No effects have been observed on both liver and body weight. PCO, CAT and LAH, showed no effect at 200 mg DINP/kg diet, corresponding with 18.2 mg/kg b.w./day. ECH appeared to be the most sensitive parameter with a dose-without-effect of 60 mg DINP/kg diet, corresponding to 5.7 mg DINP/kg b.w./day. This value of 60 mg/kg diet has been defined as overall no-observed-effect-level for DINP in this experiment.&lt;br&gt;


This item appears in the following Collection(s)

Show simple item record