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    Indicator-antigenen voor de bepaling van blootstelling aan (allergenen van) Aspergillus fumigatus in het binnenhuismilieu

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    Authors
    Wijnands LM
    van Leusden FM
    Deisz WDC
    Type
    Report
    Language
    nl
    
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    Title
    Indicator-antigenen voor de bepaling van blootstelling aan (allergenen van) Aspergillus fumigatus in het binnenhuismilieu
    Translated Title
    Indicator antigens to measure exposure to (allergens of) Aspergillus fumigatus in the indoor environment
    Publiekssamenvatting
    Blootstelling aan schimmels en schimmelproducten in het binnenhuismilieu zou kunnen leiden tot het optreden van allergieen, astma en respiratoire aandoeningen. Aangezien meting volgens klassieke methoden ontoereikend is om blootstelling aan schimmels, schimmelproducten en door schimmels geproduceerde allergenen te bepalen, wordt gezocht naar een betere methode. Onderzoek op laboratoriumschaal toont aan dat Aspergillus fumigatus antigenen produceert die onder alle gebruikte kweek-omstandigheden detecteerbaar zijn. Deze gemeenschappelijke antigenen kunnen dienen als indicator-antigenen voor blootstelling aan A.fumigatus en zijn producten. Gezien het gelijktijdig voorkomen van zowel deze gemeenschappelijke antigenen als allergenen kunnen deze indicator-antigenen gebruikt worden om blootstelling aan allergenen geproduceerd door A.fumigatus te bepalen. Aangezien het hier laboratoriumstudies betreft moet de waarde van de hier vermelde indicator-antigenen in praktijkmonsters (huisstof- en luchtmonsters) nog aangetoond worden.<br>
    Exposure to moulds and their products in the indoor environment may lead to the occurrence of allergies, asthma or respiratory complaints in general. Whereas estimation of exposure by means of enumerating viable parts is insufficient, other methods have to be developed. When grown under different circumstances in the laboratory, Aspergillus fumigatus produces a number of antigens that can be found under all studied growth conditions. These common antigens could serve as indicators for exposure to A. fumigatus and its products. In view of the simultaneous presence of these common antigens and allergens, these common antigens could serve as indicators for exposure to allergens of A. fumigatus. The value of the indicators still has to be proven by investigating house-dust and air samples.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
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