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dc.contributor.authorSomsen GW
dc.contributor.authorVisser T
dc.date.accessioned2012-12-12T15:12:42Z
dc.date.available2012-12-12T15:12:42Z
dc.date.issued1992-12-31
dc.identifier631401002
dc.identifier.urihttp://hdl.handle.net/10029/257148
dc.description.abstractAbstract niet beschikbaar
dc.description.abstractReversed-phase liquid chromatography (RP-LC) has been coupled to Fourier transform infrared spectrometry (FTIR) by means of a spray jet interface. The usefulness of the interface for impurity profiling of steriods has been demonstrated by the analysis of two samples of testosterone undecanoate. Valuable structural information on impurities >=5% was obtained either by library searching of the produced FTIR spectra, or by interpretation. Identification of two of the impurities, testosterone enanthate and testosterone decanoate, was hampered by the fact that both compounds may occur in a crystalline and in an amorphous state. The spectra of the compounds recorded in the amorphous state appeared to be highly similar.
dc.description.sponsorshipRIVM
dc.format.extent13 p
dc.language.isonl
dc.relation.ispartofRIVM Rapport 631401002
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/631401002.html
dc.subject18nl
dc.subjecttestosteronnl
dc.subjectanalysenl
dc.subjectvloeistofchromatografienl
dc.subjectinfrarood spectrometrienl
dc.subjecttestosteroneen
dc.subjectanalysisen
dc.subjectliquid chromatographyen
dc.subjectinfrared spectrophotometryen
dc.subjectrp-lcen
dc.subjectftiren
dc.title"Impurity profiling" van testosteron-undecanoaat met behulp van vloeistofchromatografie-fourier transform infraroodspectrometrienl
dc.title.alternative["Impurity profiling" of testosterone undecanoate using liquid chromatography coupled to fourier transform infrared spectrometry.]en
dc.typeReport
dc.date.updated2012-12-12T15:12:43Z
html.description.abstractAbstract niet beschikbaar
html.description.abstractReversed-phase liquid chromatography (RP-LC) has been coupled to Fourier transform infrared spectrometry (FTIR) by means of a spray jet interface. The usefulness of the interface for impurity profiling of steriods has been demonstrated by the analysis of two samples of testosterone undecanoate. Valuable structural information on impurities >=5% was obtained either by library searching of the produced FTIR spectra, or by interpretation. Identification of two of the impurities, testosterone enanthate and testosterone decanoate, was hampered by the fact that both compounds may occur in a crystalline and in an amorphous state. The spectra of the compounds recorded in the amorphous state appeared to be highly similar.


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