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    Effect van beta-HCH op humana mamma tumorcellen (MCF-7)

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    Authors
    Coosen R
    Thijssen JHH
    van Velsen FL
    Loeber JG
    Type
    Onderzoeksrapport
    Language
    nl
    
    Metadata
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    Title
    Effect van beta-HCH op humana mamma tumorcellen (MCF-7)
    Translated Title
    Effect of beta-HCH on human mamma tumor cells (MCF-7)
    Publiekssamenvatting
    Beta-HCH induceert in analogie met oestrogenen de synthese van de progesteron receptor op een dosis-gerelateerde wijze vanaf 10-7 M tot ongeveer 2,5x10-5 M (verzadigde oplossing). Een beta-HCH-metaboliet, 2,4,6-trichloorfenol (TCF), veroorzaakt in veel mindere mate inductie bij veel hogere concentraties. Beta-HCH verdringt 3H-oestradiol niet van de oestradiolreceptor in een 3x10-4-voudige overmaat, TCF niet in een 10-6-voudige overmaat. Beta-HCH (10-5 M) transloceert reeds na 0,5 uur incubatie een substantieel deel van de cytosolaire oestradiol- receptor naar de kern.<br>
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    HIL
    URI
    http://hdl.handle.net/10029/257465
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    RIVM official reports

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