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    De bepaling van Aryldone in vaccininactiveringsmedia m.b.v. hoge druk vloeistofchromatografie

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    Authors
    Derks
    H.J.G.M.
    Klaassen
    R.
    Freudenthal
    J.
    Type
    Report
    Language
    nl
    
    Metadata
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    Title
    De bepaling van Aryldone in vaccininactiveringsmedia m.b.v. hoge druk vloeistofchromatografie
    Translated Title
    Determination of Aryldone in vaccine inactivation mixtures by means of high performance liquid chromatography
    Publiekssamenvatting
    Aryldone is een stof, die mogelijk een stabiliserende invloed heeft op poliovirus-D-antigeen tijdens het formaline-inactiveringsprocede. Om de concentratie van deze stof in het inactiveringsmedium gedurende de procesgang te kunnen vervolgen is een bepalingsmethode gebaseerd op hoge druk vloeistofchromatografie ontwikkeld. Bij de kwantificering wordt gebruik gemaakt van de standaard-additiemethode om te corrigeren voor analytische verliezen. De binnen-meetserie spreiding bedraagt 1,3-1,4% terwijl de tussen-meetserie spreiding 8-9% is.
    Abstract not available
    Sponsors
    RIVM
    URI
    http://hdl.handle.net/10029/257548
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